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Adrenergic Receptor Interactions
Published by Anonymous on 2007/9/30 (2434 reads)
1: Hypertension. 1988 Mar;11(3 Pt 2):II21-9.

Beta-adrenergic receptor blockers. Adverse effects and drug interactions.

Frishman WH.

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.

Adverse effects of beta-adrenergic receptor blocking drugs can be divided into two categories: 1) those that result from known pharmacological consequences of beta-adrenergic receptor blockade; and 2) other reactions that do not appear to result from beta-adrenergic receptor blockade. Adverse effects of the first type include bronchospasm, heart failure, prolonged hypoglycemia, bradycardia, heart block, intermittent claudication, and Raynaud's phenomenon. Neurological reactions include depression, fatigue, and nightmares. It is not yet proven whether the beta 1-selective adrenergic blockers or those with partial agonist activity reduce the overall frequency of adverse reactions seen with propranolol. Patient age does not appear, in itself, to be associated with more beta-blocker side effects. Side effects of the second category are rare. They include an unusual oculomucocutaneous reaction and the possibility of oncogenesis. There are also many drugs that interact with beta-blockers, which may increase toxicity. Finally, there are specific patient characteristics where one beta-blocker may be more effective and safer than another.

Publication Types:

PMID: 2895072 [PubMed - indexed for MEDLINE]


2: Biochimie. 1984 Jul-Aug;66(7-8):IX-XIV.

[The adipose cell: a convenient experimental model for analysing the functional interactions of 2 adrenergic receptors as effected by antagonists, the alpha 2- and beta receptor]

[Article in French]

Berlan M, Lafontan M.

Publication Types:

PMID: 6099147 [PubMed - indexed for MEDLINE]

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