1: Mol Pharmacol. 2003 May;63(5):959-60.


Comment on:
Mol Pharmacol. 2003 May;63(5):1104-16.

An array of details on G-protein coupled receptor signaling: differential effects of alpha1-adrenergic receptor subtypes on gene expression and cytokine receptor signaling.

Nathanson NM.

Department of Pharmacology, University of Washington, Seattle 98195-7750, USA. nathanso@u.washington.edu

Publication Types:
Comment
Review

PMID: 12695523 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

2: Rev Physiol Biochem Pharmacol. 1999;136:183-223.


Regulation of beta-adrenergic receptor responsiveness modulation of receptor gene expression.

Danner S, Lohse MJ.

Institute of Pharmacology, University of Würzburg, Germany.

Publication Types:
Research Support, Non-U.S. Gov't
Review

PMID: 9932487 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

3: Annu Rev Pharmacol Toxicol. 1998;38:351-73.


Insights from in vivo modification of adrenergic receptor gene expression.

Rohrer DK, Kobilka BK.

Department of Molecular and Cellular Physiology, Stanford University, California 94305, USA.

Adrenergic receptors are key targets within the autonomic nervous system, regulating a wide variety of physiological processes. The ability to modify adrenergic receptor expression patterns in vivo has added a powerful new tool to the functional analysis of these receptors. Modification of adrenergic receptor gene expression by overexpression, genetic ablation, or site-specific mutation has added new insight to models of receptor coupling behavior, pharmacology, and subtype-specific physiological function. This review highlights some of the recent advances resulting from such genetic approaches to the study of adrenergic receptors.

Publication Types:
Review

PMID: 9597159 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

4: Annu Rev Physiol. 1991;53:497-508.


Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.

Collins S, Caron MG, Lefkowitz RJ.

Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710.

Multiple mechanisms contribute to the regulation of G protein-coupled receptors and their transmembrane signaling. Post-translational modifications of the receptors, such as phosphorylation, and changes in receptor gene expression can occur in either a strictly agonist-dependent fashion or through second messenger-mediated autoregulation. We have shown that modulation of receptor gene expression contributes to the responsiveness of adrenergic and related receptors. Recent evidence for post-transcriptional regulation, as well as the stimulation of transcription in an autoregulatory manner, indicates the unanticipated variety and complexity of mechanisms regulating adrenergic receptor responsiveness.

Publication Types:
Review

PMID: 2042970 [PubMed - indexed for MEDLINE]