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Beta-Catenin Function
Published by Anonymous on 2007/9/29 (1965 reads)
1: Tanpakushitsu Kakusan Koso. 2001 Mar;46(3):197-207.

[Beta-catenin: its discovery as a cadherin-associated protein and its function as a transcription activator]

[Article in Japanese]

Ozawa M.


Publication Types:

PMID: 11244716 [PubMed - indexed for MEDLINE]


2: Oncogene. 1999 Dec 20;18(55):7860-72.

Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways.

Miller JR, Hocking AM, Brown JD, Moon RT.

Department of Pharmacology and Center for Developmental Biology, Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA.

Communication between cells is often mediated by secreted signaling molecules that bind cell surface receptors and modulate the activity of specific intracellular effectors. The Wnt family of secreted glycoproteins is one group of signaling molecules that has been shown to control a variety of developmental processes including cell fate specification, cell proliferation, cell polarity and cell migration. In addition, mis-regulation of Wnt signaling can cause developmental defects and is implicated in the genesis of several human cancers. The importance of Wnt signaling in development and in clinical pathologies is underscored by the large number of primary research papers examining various aspects of Wnt signaling that have been published in the past several years. In this review, we will present a synopsis of current research with particular attention paid to molecular mechanism of Wnt signal transduction and how the mis-regulation of Wnt signaling leads to cancer.

Publication Types:

PMID: 10630639 [PubMed - indexed for MEDLINE]


3: Curr Top Dev Biol. 1997;35:161-89.

beta-Catenin is a target for extracellular signals controlling cadherin function: the neurocan-GalNAcPTase connection.

Lilien J, Balsamo J, Hoffman S, Eisenberg C.

Department of Biological Sciences, Wayne State University, Detroit, Michigan 48230, USA.

Publication Types:
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

PMID: 9292270 [PubMed - indexed for MEDLINE]

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