Caspase Expression
Published by Anonymous on 2007/9/29 (2354 reads)
1: Cell Death Differ. 1999 Dec;6(12):1201-8.
Comment in:
Cell Death Differ. 1999 Dec;6(12):1144-5.
From PTK-STAT signaling to caspase expression and apoptosis induction.
Fu XY.
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, CT 06520, USA. xin-yuan.fu@yale.edu
The cell growth and survival can be regulated by cytokine induced signals. Nevertheless, the molecular mechanisms of signal transduction from cytokine receptors to mediators of cell growth and apoptosis are not well characterized. STAT (signal transducer and activator of transcription) proteins can be activated by protein tyrosine kinases (PTK) in response to a variety of cytokines. We have shown that STAT activation induces expression of caspases which may cause cells undergo apoptosis. A hypothesis is proposed that PTKSTAT signaling pathways can regulate induction of apoptosis in response to cytokines and other extracellular signals.
Publication Types:
Review
PMID: 10637436 [PubMed - indexed for MEDLINE]
Comment in:
Cell Death Differ. 1999 Dec;6(12):1144-5.
From PTK-STAT signaling to caspase expression and apoptosis induction.
Fu XY.
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, CT 06520, USA. xin-yuan.fu@yale.edu
The cell growth and survival can be regulated by cytokine induced signals. Nevertheless, the molecular mechanisms of signal transduction from cytokine receptors to mediators of cell growth and apoptosis are not well characterized. STAT (signal transducer and activator of transcription) proteins can be activated by protein tyrosine kinases (PTK) in response to a variety of cytokines. We have shown that STAT activation induces expression of caspases which may cause cells undergo apoptosis. A hypothesis is proposed that PTKSTAT signaling pathways can regulate induction of apoptosis in response to cytokines and other extracellular signals.
Publication Types:
Review
PMID: 10637436 [PubMed - indexed for MEDLINE]
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