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Lysozyme Structure
Published by Anonymous on 2007/9/29 (2261 reads)
1: Clin Chim Acta. 2005 Jul 24;357(2):168-72.


Lysozyme: a paradigmatic molecule for the investigation of protein structure, function and misfolding.

Merlini G, Bellotti V.

Biotechnology Research Laboratory, University Hospital IRCCS Policlinico San Matteo, Department of Biochemistry, University of Pavia, P.le Golgi, 2, 27100 Pavia, Italy. gmerlini@unipv.it

BACKGROUND: The term amyloidosis encompasses a wide group of conditions characterised by the tissue deposition of autologous proteins assembled in homogeneous regularly spaced antiparallel beta strands. The mechanism by which the different proteins gain a conformation, allowing monomers to bind to each other to form the regular amyloid fibril, is under intensive investigation. The discovery that human lysozyme, a protein thoroughly structurally and functionally characterised, can form amyloid fibrils has offered unique opportunities to unveil the molecular mechanisms involved in amyloid formation. Four amyloidogenic mutations have been identified and an apparently non-amyloidogenic polymorphism has been recently described. RESULTS AND CONCLUSIONS: Lysozyme is well characterised for structure, function, folding dynamics and metabolism and comparative studies are becoming available that highlight pathogenic differences between the wild-type and the amyloidogenic variants. The chemical structure of lysozyme in natural amyloid fibrils was characterised in high detail in the early cases, but it is still lacking in the cases most recently discovered. Amyloidogenic lysozymes represent a prototypic molecule for new pharmaceutical approaches in which the formation of amyloid fibrils is abrogated through a stabilisation of the precursor.

Publication Types:
Research Support, Non-U.S. Gov't
Review

PMID: 15913589 [PubMed - indexed for MEDLINE]

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2: J Bacteriol. 1994 Nov;176(22):6783-8.


Genetic analysis of bacteriophage T4 lysozyme structure and function.

Poteete AR, Hardy LW.

Department of Molecular Genetics & Microbiology, University of Massachusetts Medical Center, Worcester.

Publication Types:
Research Support, U.S. Gov't, P.H.S.
Review

PMID: 7961435 [PubMed - indexed for MEDLINE]

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3: Adv Protein Chem. 1991;41:173-315.


Lysozyme and alpha-lactalbumin: structure, function, and interrelationships.

McKenzie HA, White FH Jr.

Department of Chemistry, University College, University of New South Wales, Australian Defence Force Academy, Canberra, ACT, Australia.

Publication Types:
Review

PMID: 2069076 [PubMed - indexed for MEDLINE]

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4: Mol Cell Biochem. 1982 May 14;44(3):129-48.


Implication of the structure and stability of disulfide intermediates of lysozyme on the mechanism of renaturation.

Acharya AS, Taniuchi H.

Publication Types:
Research Support, U.S. Gov't, P.H.S.
Review

PMID: 7050652 [PubMed - indexed for MEDLINE]

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5: CRC Crit Rev Biochem. 1979;6(4):371-400.


Determination of the entire antigenic structure of native lysozyme by surface-simulation synthesis, a novel concept in molecular recognition.

Atassi MZ.

Publication Types:
Research Support, U.S. Gov't, P.H.S.
Review

PMID: 88298 [PubMed - indexed for MEDLINE]

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6: Czas Stomatol. 1969 Mar;22(3):213-9.


[Lysozyme. I. Structure and properties]

[Article in Polish]

Szymczyk T, Gratkowska H, Kozlowska I.

Publication Types:
Review

PMID: 4888456 [PubMed - indexed for MEDLINE]
 

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