Sodium Potassium ATPase Expression
Published by Anonymous on 2007/9/29 (1896 reads)
1: Nippon Rinsho. 1993 Jun;51(6):1504-10.
[Na, K-ATPase gene expression in hypertrophic and failing hearts]
[Article in Japanese]
Ikeda U, Tsuruya Y, Yamamoto K.
Department of Cardiology, Jichi Medical School.
Na, K-ATPase (Na, K-pump) maintains intracellular ion composition by transporting Na+ and K+ across the cell membrane, and plays an important role in many fundamental cellular and physiological processes such as the control of contractility, excitability, and cell volume regulation. The Na, K-ATPase protein comprises two subunits, a large catalytic alpha subunit and a smaller glycosylated beta subunit. At least three alpha subunit isoforms, alpha 1, alpha 2 and alpha 3, and two beta subunit isoforms, beta 1 and beta 2, have been characterized in rats and humans. The expression of Na, K-ATPase alpha and beta subunits in cardiocytes is directly regulated at a transcriptional level by hormones and ions, such as thyroid hormone and Na+. In the hypertrophic and failing hearts, the expression of cardiac Na, K-ATPase gene is altered, and which might play an important role in the pathogenesis of those disorders.
Publication Types:
English Abstract
Review
PMID: 8391594 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
2: Biochim Biophys Acta. 1985 Dec 9;822(3-4):335-53.
Interaction of (Na+ + K+)-ATPase with artificial membranes. II. Expression of partial transport reactions.
Anner BM.
Publication Types:
Research Support, Non-U.S. Gov't
Review
PMID: 2415163 [PubMed - indexed for MEDLINE]
[Na, K-ATPase gene expression in hypertrophic and failing hearts]
[Article in Japanese]
Ikeda U, Tsuruya Y, Yamamoto K.
Department of Cardiology, Jichi Medical School.
Na, K-ATPase (Na, K-pump) maintains intracellular ion composition by transporting Na+ and K+ across the cell membrane, and plays an important role in many fundamental cellular and physiological processes such as the control of contractility, excitability, and cell volume regulation. The Na, K-ATPase protein comprises two subunits, a large catalytic alpha subunit and a smaller glycosylated beta subunit. At least three alpha subunit isoforms, alpha 1, alpha 2 and alpha 3, and two beta subunit isoforms, beta 1 and beta 2, have been characterized in rats and humans. The expression of Na, K-ATPase alpha and beta subunits in cardiocytes is directly regulated at a transcriptional level by hormones and ions, such as thyroid hormone and Na+. In the hypertrophic and failing hearts, the expression of cardiac Na, K-ATPase gene is altered, and which might play an important role in the pathogenesis of those disorders.
Publication Types:
English Abstract
Review
PMID: 8391594 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
2: Biochim Biophys Acta. 1985 Dec 9;822(3-4):335-53.
Interaction of (Na+ + K+)-ATPase with artificial membranes. II. Expression of partial transport reactions.
Anner BM.
Publication Types:
Research Support, Non-U.S. Gov't
Review
PMID: 2415163 [PubMed - indexed for MEDLINE]
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