Potassium Channel Expression
Published by Anonymous on 2007/9/27 (2204 reads)
1: Crit Rev Biochem Mol Biol. 2004 May-Jun;39(3):125-45.
Determinants of voltage-gated potassium channel surface expression and localization in Mammalian neurons.
Misonou H, Trimmer JS.
Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA.
Neurons strictly regulate expression of a wide variety of voltage-dependent ion channels in their surface membranes to achieve precise yet dynamic control of intrinsic membrane excitability. Neurons also exhibit extreme morphological complexity that underlies diverse aspects of their function. Most ion channels are preferentially targeted to either the axonal or somatodendritic compartments, where they become further localized to discrete membrane subdomains. This restricted accumulation of ion channels enables local control of membrane signaling events in specific microdomains of a given compartment. Voltage-dependent K+ (Kv) channels act as potent modulators of diverse excitatory events such as action potentials, excitatory synaptic potentials, and Ca2+ influx. Kv channels exhibit diverse patterns of cellular expression, and distinct subtype-specific localization, in mammalian central neurons. Here we review the mechanisms regulating the abundance and distribution of Kv channels in mammalian neurons and discuss how dynamic regulation of these events impacts neuronal signaling.
Publication Types:
Review
PMID: 15596548 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
2: J Neurobiol. 1998 Oct;37(1):69-79.
When, where, and how much? Expression of the Kv3.1 potassium channel in high-frequency firing neurons.
Gan L, Kaczmarek LK.
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
The Kv3.1 potassium channel gene is expressed in neurons that fire action potentials at high frequencies. Neurons that express this gene, such as auditory brain stem neurons, have high-threshold voltage-dependent potassium currents that activate and deactivate unusually rapidly, and whose characteristics match those of the Kv3.1 subunit expressed heterologously. The level of Kv3.1 expression in neurons is regulated during development and by environmental stimuli. Pharmacological and computer modeling studies indicate that changes in the level of this channel alter the ability of a neuron to follow synaptic inputs at high frequencies. To understand the transcriptional mechanisms that control Kv3.1 expression, an initial characterization of the primary promoter for the Kv3.1 gene was carried out. This review summarizes current knowledge regarding Kv3.1 gene transcription and the roles of upstream regulatory elements in conferring cell-type specificity and long-term regulation by extrinsic factors.
Publication Types:
Review
PMID: 9777733 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
3: Nippon Ika Daigaku Zasshi. 1998 Feb;65(1):73-5.
Molecular cloning and functional expression of the human heart inwardly-rectifying potassium channel.
Takeda J, Koumi S, Sato R, Hayakawa H.
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, USA.
Publication Types:
Review
PMID: 9513373 [PubMed - indexed for MEDLINE]
Determinants of voltage-gated potassium channel surface expression and localization in Mammalian neurons.
Misonou H, Trimmer JS.
Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA.
Neurons strictly regulate expression of a wide variety of voltage-dependent ion channels in their surface membranes to achieve precise yet dynamic control of intrinsic membrane excitability. Neurons also exhibit extreme morphological complexity that underlies diverse aspects of their function. Most ion channels are preferentially targeted to either the axonal or somatodendritic compartments, where they become further localized to discrete membrane subdomains. This restricted accumulation of ion channels enables local control of membrane signaling events in specific microdomains of a given compartment. Voltage-dependent K+ (Kv) channels act as potent modulators of diverse excitatory events such as action potentials, excitatory synaptic potentials, and Ca2+ influx. Kv channels exhibit diverse patterns of cellular expression, and distinct subtype-specific localization, in mammalian central neurons. Here we review the mechanisms regulating the abundance and distribution of Kv channels in mammalian neurons and discuss how dynamic regulation of these events impacts neuronal signaling.
Publication Types:
Review
PMID: 15596548 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
2: J Neurobiol. 1998 Oct;37(1):69-79.
When, where, and how much? Expression of the Kv3.1 potassium channel in high-frequency firing neurons.
Gan L, Kaczmarek LK.
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
The Kv3.1 potassium channel gene is expressed in neurons that fire action potentials at high frequencies. Neurons that express this gene, such as auditory brain stem neurons, have high-threshold voltage-dependent potassium currents that activate and deactivate unusually rapidly, and whose characteristics match those of the Kv3.1 subunit expressed heterologously. The level of Kv3.1 expression in neurons is regulated during development and by environmental stimuli. Pharmacological and computer modeling studies indicate that changes in the level of this channel alter the ability of a neuron to follow synaptic inputs at high frequencies. To understand the transcriptional mechanisms that control Kv3.1 expression, an initial characterization of the primary promoter for the Kv3.1 gene was carried out. This review summarizes current knowledge regarding Kv3.1 gene transcription and the roles of upstream regulatory elements in conferring cell-type specificity and long-term regulation by extrinsic factors.
Publication Types:
Review
PMID: 9777733 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
3: Nippon Ika Daigaku Zasshi. 1998 Feb;65(1):73-5.
Molecular cloning and functional expression of the human heart inwardly-rectifying potassium channel.
Takeda J, Koumi S, Sato R, Hayakawa H.
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, USA.
Publication Types:
Review
PMID: 9513373 [PubMed - indexed for MEDLINE]
| Navigate through the articles | |
Potassium Channel Structure
|
|
|
|