1: Semin Immunol. 2000 Aug;12(4):349-59.


The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function.

Alexander DR.

Laboratory of Lymphocyte Signalling and Development, Programme of Molecular Immunology, The Babraham Institute, Cambridge, CB2 4AT, UK. Denis.Alexander@BBSRC.AC.UK

The CD45 phosphotyrosine phosphatase is one of the most abundant glycoproteins expressed on immune cells. Previously, the serpentine twists and turns of the CD45 research field have tended to draw attention to CD45 either as a positive or negative regulator of immune cell function. This review draws heavily on CD45 knockout mouse data to emphasize that CD45 has both positive and negative actions in regulating receptor thresholds, and these roles vary according to cell lineage and developmental stage. Previously conflicting results are reconciled in a model suggesting how CD45 regulates the p56(lck)tyrosine kinase in T cell signalling and development. Copyright 2000 Academic Press.

Publication Types:
Research Support, Non-U.S. Gov't
Review

PMID: 10995582 [PubMed - indexed for MEDLINE]

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2: Postepy Biochem. 1998;44(3):208-15.


[CD45, antigen with phosphatase activity, structure; function and role in T lymphocyte activation]

[Article in Polish]

Bohr I, Gniot-Szulzycka J.

Zakład Biochemii, Instytut Biologii Ogólnej i Molekularnej, Uniwersytet Mikołaja Kopernika, Toruń.

Publication Types:
Review

PMID: 10022039 [PubMed - indexed for MEDLINE]

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3: Biochem Soc Trans. 1992 Feb;20(1):174-8.


Regulation and structure-function relationship of CD45.

Trowbridge IS, Johnson P, Ostergaard H, Hole N.

Department of Cancer Biology, Salk Institute, San Diego, CA 92186-5800.

Publication Types:
Research Support, U.S. Gov't, P.H.S.
Review

PMID: 1386037 [PubMed - indexed for MEDLINE]

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4: Adv Exp Med Biol. 1992;323:29-37.


Structure and function of CD45: a leukocyte-specific protein tyrosine phosphatase.

Trowbridge IS, Johnson P, Ostergaard H, Hole N.

Department of Cancer Biology, Salk Institute, San Diego, CA 92186-5800.

Publication Types:
Research Support, U.S. Gov't, P.H.S.
Review

PMID: 1485564 [PubMed - indexed for MEDLINE]